In this episode, billionaire Brian Johnson returns to discuss his ambitious project, Blueprint, aimed at extending human life through meticulous health and wellness management. Brian candidly shares his own experiences, revealing significant improvements in lifespan extension, muscle strength, sleep quality, and overall peak performance. He also delves into the psychological aspects of self-awareness and the biases that cloud human judgment. Furthermore, Kate Tolo, the first woman to adopt Brian's lifestyle, discusses the challenges and revelations she faced in her transformative journey. The conversation touches on the importance of air quality, the potential of gene therapy, and the societal shift from grind culture to prioritizing health. Brian and Kate emphasize the need to reconsider societal norms, like sugar consumption, and the importance of data-driven health decisions over traditional habits.
"That is how you can measure your nighttime erections. It's unbelievable. In ways it improves health and wellness."
This quote highlights Brian Johnson's belief in the health benefits of measuring nighttime erections, suggesting that it is an effective method for health improvement.
"The billionaire who's spending $2 million a year to stay young forever. Through algorithmic precision, this is the most impactful humanitarian project ever. Trying to find the very best science in the world for how you can extend your life."
Brian Johnson is investing in anti-aging research with the goal of staying young indefinitely, viewing it as a significant humanitarian endeavor to find the best scientific methods for life extension.
"Honestly, I'm in the absolute peak performance of my entire life. I've extended my lifespan over 30%, reduced my age by twelve years, increased muscle and strength, and now six months of perfect sleep. I've accomplished the best sleep score in history."
The quote details Brian Johnson's personal achievements in anti-aging, suggesting that his methods have significantly improved his quality of life and could be replicated by others.
"Sleep is the single most important thing any human does on any given day."
This quote underscores the significance Brian Johnson places on sleep, considering it the most crucial daily activity for human health and performance.
"Dealing with oneself is the most challenging thing. This is from my experience, the most challenging thing in my existence is understanding my own self."
The quote reflects on the difficulty of self-awareness and the tendency for people to be unaware of their own biases and limitations.
"Oh, man, it's like my most favorite topic. Because we are fooled into thinking that we truly understand our situation, our reality."
This quote expresses Brian Johnson's interest in the concept of priming and how it reveals that people often do not fully understand their own behaviors and motivations.
"There's a difference between the acknowledgment that sleep may be good for you, and you say, yeah, I'm on board of good sleep. It's an entirely different situation when you prioritize your life around that."
The quote distinguishes between mere acknowledgment of the benefits of sleep and actively prioritizing sleep in one's lifestyle, highlighting the importance of discipline in making health-conscious decisions.
"I wanted to say, okay, if you really take don't die to the absolute extreme, I'm going to measure every biological process in my body and find out where every cell is aging, like basically where dying is happening."
Brian Johnson explains his blueprint's goal to meticulously measure and prevent the aging process at the cellular level, taking the concept of not dying to its extreme.
"Increasingly, that opens up an expanse of opportunity that is so far beyond our imagination, we can't even begin to pretend like we understand."
The quote conveys Brian Johnson's vision of a future where AI allows for unprecedented control over our reality, presenting possibilities that are currently unimaginable.
"That's just an engineering problem. It's public policy."
This quote from Brian Johnson minimizes the concern of wealth disparities associated with increased longevity, framing it as a solvable problem through policy and engineering rather than a fundamental obstacle to pursuing life extension.
"When we started learning how to engineer biology. This is what I spent the past ten years doing is." "We need this foundational technology so that any problem in the physical world, whether it be our health, the health of the oceans, anything, building a global biological immune system, we need to have these physical abilities."
The quotes elaborate on the moment humans began to take control over the development of life through biological engineering, and Brian Johnson's vision for using this technology to address a wide range of physical world problems.
"Kernel is a way for us to use science and data to build our best cognitive existence." "A kernel is to buy a helmet. You put it on your head, and you find out important information about your brain."
These quotes introduce Kernel as a tool for enhancing cognitive health and explain the practical application of the technology in providing brain data.
"I had my brain measured for ten minutes a day, for five days before, during the ketamine experience, and then 14 days afterwards." "There was that one to three day therapeutic window where I was very open to new pattern creation."
The quotes describe the process of measuring brain activity before, during, and after a psychedelic experience, and the observed changes in brain patterns that suggest a therapeutic potential for psychedelics.
"They're powerful. Yeah. And I hope that kernel accelerates their progress because most of the measurements are done through questionnaires." "Having a system that tracks the data removes some of that challenge."
Brian Johnson discusses the potential for Kernel to validate the efficacy of psychedelics in mental health, highlighting the superiority of data over subjective accounts.
"Then, Jesus, I can't trust much, can I?" "What do we really know about anything? And like you said, this one little plant, and you eat it, you ingest it, and then somehow your reality is absolutely transformed into something that you never imagined was possible."
These quotes capture the profound impact of psychedelics on the perception of reality, as recounted by the host and Brian Johnson, and their implications for understanding consciousness and reality.
"Computational intelligence on near future timelines are going to be far superior to our form of intelligence." "We're walking into the cradle of super intelligence."
These quotes outline Brian Johnson's perspective on the rapid advancement of artificial intelligence and its implications for the future of human experience and evolution.
"I'm convinced by my thought experiment that they look back and be like, of course, in the early 21st century, Homo sapiens figured out that they had developed the technology to continually expand their life and that the homo sapien culture shifted to the preservation of life." "Why would we even begin to imagine that we can express an opinion that is meaningful?"
Brian Johnson expresses his conviction in the life extension movement and the inevitability of significant technological advances in this field, suggesting that current perspectives on the future may be too limited.
"But to punch through 120 is very difficult through lifestyle and diet and exercise. And so to really punch through this ceiling, you need to start working at the genetic level." "This gene therapy didn't change my actual genes. It just increases the expression of full statin in my body."
These quotes explain the limitations of traditional methods for extending lifespan and introduce gene therapy as a method to significantly enhance human health and longevity.
"You need to see it working in your body. Otherwise, be careful when you're doing it." "They reliably maintain my IC NAd levels at an 18 year old level."
Brian Johnson emphasizes the need for empirical evidence when evaluating anti-aging therapies and shares his personal experience with maintaining youthful levels of NAD+ through specific supplements.
"Extra virgin olive oil is very close to number one. You really." "It's better than ozempic."
These quotes highlight the significant health benefits associated with high-quality extra virgin olive oil and Brian Johnson's efforts to make such a product widely available.
"So everybody should know three things. How much you weigh, how fast you're aging, and the duration of your nighttime erections." "You could potentially slow your speed of aging to 0.6, which means while all of your friends are aging at a normal rate, you would get September, October, November and December for free."
These quotes describe the importance of measuring specific health indicators to track and potentially improve one's health and longevity.
"And then this data, it's really important because it represents psychological health, sexual health, cardiovascular health."
This quote highlights the significance of tracking nighttime erections as they are not just a sexual function but also an indicator of overall health.
"So my current erection amount is equal to roughly my chronological age. For me to be equal to an 18 year old, I would need 3 hours and 30 minutes."
Brian Johnson explains his personal findings and sets a goal based on the average duration of an 18-year-old's nighttime erections.
"We're wondering if you take this therapy, this focus shockwave therapy, and if it will just basically rejuvenate the penis and increase nighttime erections."
Brian Johnson discusses the potential benefits of focused shockwave therapy in rejuvenating the penis and enhancing nighttime erections.
"My subjective experience is, it's as if my Penis has gotten like 15 years younger."
This quote reflects Brian Johnson's personal experience with shockwave therapy, suggesting a subjective improvement in the condition of his penis.
"We've increased cheating."
Brian Johnson mentions that using electromagnetic technology has led to muscle improvements, as observed in MRI scans.
"And it's improved the structure of my penis."
Here, Brian Johnson correlates the treatment he's been undergoing for hair loss with an improvement in the physical structure of his penis, suggesting a broader impact on his body's condition.
"So there's a lot of sustained damage that's just hard to undo."
This quote emphasizes the importance of maintaining good air quality to prevent long-term health damage.
"I reached out to him and across every medium, so literally his medium, articles, email, social media, and I never heard back."
Kate Tolo describes her persistent efforts to connect with Brian Johnson, which eventually led to their collaboration.
"My baseline fitness testing, for example, put me on an average of, like, age 60 or age 70, just based on my flexibility, my strength, my cardiovascular health, all those kinds of things."
Kate Tolo shares the surprising results of her initial fitness testing, which did not align with her external appearance of health.
"My leg press one rep max went from 220 pounds to 360 pounds in 30 days."
Kate Tolo provides a specific example of her physical improvements after following the blueprint protocol for 30 days.
"I'm a grind culture child. I really did throw myself into it."
This quote emphasizes Kate's identification with grind culture and her strong work ethic, which has significantly influenced her social life.
"It's just so sad. But the first thing that comes to my mind is oat milk lattes."
Kate uses the example of missing oat milk lattes to illustrate the emotional impact of changing everyday habits and the sacrifices involved in adapting to a new lifestyle.
"You can't let those things drive you when you're on blueprint."
Kate acknowledges the tension between external pressures and the need to focus on personal health metrics, highlighting the importance of data in guiding her decisions.
"It was Kate's call to do it. And even when she was doing it, it was entirely her decision whether she wanted to continue."
Brian's statement reinforces the idea that Kate had autonomy over her decision to engage with the blueprint program, highlighting the importance of personal choice in such commitments.
"I don't mind the idea of death. If it happens, it happens. But I would love to be able to spend each minute living as much as possible."
Kate expresses her acceptance of death but emphasizes her desire to live life fully, reflecting on the value she places on the quality of life over the fear of death.
"What I hope is we've given a blueprint for the future evolution of being human, and we've made everything available for free for everyone all over the world."
Brian's quote highlights his ambition to share knowledge and resources for the betterment of human health and evolution, emphasizing the accessibility and openness of the blueprint program.
"Regardless of the data and how I feel and all these kinds of things, the thing that I always come back to on whether or not this is the right decision for me, as in blueprint is who's doing a better job of looking after Kate."
Kate's contemplation on self-improvement and care demonstrates her commitment to making choices that enhance her well-being, using the blueprint program as a tool for personal growth.
"The majority of that has been on the measurement protocols. It's the scientific research."
Brian explains the significant investment in scientific research and measurement protocols for the blueprint program, emphasizing the thorough approach taken to ensure the program's effectiveness and accuracy.
"I really see myself as an operations manager for humanity."
Kate's self-description as an operations manager for humanity reflects her focus on large-scale systems and her role in implementing efficient solutions for global challenges.
"I read all the comments. I find it to be a really informative source about what I'm doing well to communicate what I'm struggling on."
Brian's appreciation for community feedback shows his commitment to improving communication and his respect for the audience's perspective.
"How lucky are we to exist in this moment? And if we're really trying to figure out how we have the most fulfilling existence, prioritizing our health and wellness... changes your existence."
Brian's philosophical musings on existence and well-being underscore the transformative power of prioritizing health and the potential for a more fulfilling life as a result.